Sharon Osbourne reacts to Ozzy Osbourne 2026 Grammy tribute
Sharon Osbourne is taking a moment to praise the Ozzy Osbourne tribute at the 2026 Grammy Awards.
On February 1, Post Malone, Chad Smith, Duff McKagan, Slash and Andrew Watt took to the stage during the awards show and performed the late Black Sabbath rocker’s War Pigs in order to honor the late artist.
For those unversed, Ozzy passed away in July 2025. He was 76.
Sharon, who also attended the show and was moved by the tribute, wrote on her social media, “Last night was bigger than a performance. It was a moment carved into musical history. Reminding everyone that rock isn’t nostalgia – it’s alive, evolving, and still the heartbeat of music.”
The TV personality also posted a video from the ceremony, giving special shout-outs to the performers.
“@postmalone you were pure magic, a shapeshifter with a voice that can bend into any genre. @slash @duffmckagan @thisiswatt @chadsmithofficial you are the masters of your craft and complete icons.”
“Truly from the bottom of my heart, thank you Ozzy was definitely in the building,” she concluded.
Health officials are warning the public of potential measles exposure after an international traveler visited several high-traffic locations in Southern California, including Los Angeles International Airport (LAX) and the Disneyland Resort.
The traveler arrived Jan. 26 on Viva Aerobus Flight 518 at Tom Bradley International Terminal B, Gate 201A, according to a statement from the Los Angeles County Department of Public Health (LADPH).
The department stated that individuals who were in Terminal B between 10:45 p.m. Jan. 26 and 1 a.m. Jan. 27 may have been exposed.
Following the arrival, the individual traveled to Orange County. The Orange County Health Care Agency shared the following exposure windows for Jan. 28.
Goofy’s Kitchen (Disneyland Hotel) between 10:30 a.m. and 1:30 p.m.
Disneyland Park and Disney California Adventure from 12:30 p.m. until park closure
Goofy’s Kitchen in Disneyland Hotel was one site of potential measles exposure.(Photo by AaronP/Bauer-Griffin/GC Images)
A subsequent exposure was identified on Jan. 30 at a Dunkin’ Donuts in Woodland Hills, according to the LADPH.
“People who were at these locations during these times may be at risk of developing measles from seven to 21 days after exposure,” the Orange County Health Care Agency said in a statement.
Health officials advise anyone who visited these locations during the specified windows to check their immunization status and monitor for symptoms for 21 days following exposure.
Public health departments in both Los Angeles and Orange County will continue to track potential exposure sites and notify individuals at high risk.
People should contact a healthcare provider by phone before visiting a clinic if symptoms develop to prevent further spread, experts recommend.
The infected passenger was an international traveler at Los Angeles International Airport (LAX).(KENA BETANCUR/AFP via Getty Images)
Fox News Digital reached out to county officials for a statement.
What to know about measles
Measles is a highly contagious viral disease. If one person is infected, up to 90% of nearby people who are not immune will also become infected, according to the Centers for Disease Control and Prevention.
“Measles doesn’t only affect people who travel internationally — everyone is at risk if they’re not protected,” said Dr. Anissa Davis, deputy county health officer for Long Beach, California. “The best way to protect yourself and your loved ones is to get vaccinated before exposure occurs.”
Visitors at Disneyland on the listed dates and times should exercise caution and limit contact with others, according to experts.(Getty Images)
Symptoms of measles typically include fever, cough, runny nose and red eyes, followed by a characteristic rash that begins on the face and spreads downward, per the CDC. An infected person is contagious for four days before and four days after the rash appears.
As of Jan. 30, there have been 588 confirmed cases of measles in the U.S. so far in 2026, the agency reports. This follows a significant surge in 2025, which saw 2,267 cases — the highest annual count in more than three decades.
Khloe Quill is a lifestyle production assistant with Fox News Digital. She and the lifestyle team cover a range of story topics including food and drink, travel, and health.
Jeffrey Epstein (left) and Peter Mandelson are seen on a yacht in a photo from the latest release of Epstein files. — US Department of Justice
Starmer’s government hands Mandelson material to police.
Ex-UK envoy to US accused of leaking market-sensitive material.
Mandelson faces possible criminal charges after emails released by US.
British police on Tuesday launched an investigation into Peter Mandelson, Britain’s former ambassador to the US, over alleged misconduct in public office, following claims that he leaked market-sensitive information to the late sex offender Jeffrey Epstein.
London’s Metropolitan Police said in a statement that the investigation follows the receipt of reports alleging misconduct in public office, including a referral from the British government.
Prime Minister Keir Starmer’s government handed material to the police to investigate whether Mandelson leaked information to Epstein during the financial crash.
Starmer told his ministers on Tuesday that Mandelson’s alleged leaks to Epstein were “disgraceful.” A few hours later, Mandelson said he would retire from parliament’s upper house, the House of Lords.
“The Met will continue to assess all relevant information brought to our attention as part of this investigation and won’t be commenting any further at this time,” Police Commander Ella Marriott said.
Separately, Thames Valley Police said in a statement they were reviewing a new claim against the former Prince Andrew.
Mandelson, a major player in the Labour governments of Tony Blair and Gordon Brown more than two decades ago, is facing possible criminal charges after emails released by the US as part of the Epstein investigation suggested he had leaked confidential government documents to the financier.
The Times newspaper, which first reported the police investigation, said officers were expected to interview Mandelson and take statements from senior Labour figures, including former Prime Minister Brown.
Following the announcement of the investigation into Mandelson, a government spokesperson said it stood “ready to provide whatever support and assistance the police need.”
The emails suggest that in 2009, Mandelson sent Epstein a memo written for Brown about possible UK asset sales and tax changes, and in 2010, gave Epstein advance notice of a 500-billion-euro ($590 billion) bailout by the European Union.
Mandelson, 72, was fired from his ambassadorial role in September, seven months after being appointed, after documents emerged showing he had remained close to Epstein for much longer than he had previously acknowledged.
In one message, he appeared to tell Epstein that his earlier conviction, for procuring a child for prostitution, was wrong and he should fight for early release.
On Tuesday, Starmer told his cabinet he was not reassured that the totality of the information had yet emerged, according to his spokesperson.
His comments marked his strongest condemnation yet of the man he appointed ambassador to Washington last year despite his known association with Epstein, who committed suicide in prison in 2019.
“The prime minister said he was appalled by the information that had emerged over the weekend in the Epstein files,” his spokesperson said.
Late on Sunday, Mandelson resigned from the Labour Party to prevent “further embarrassment”, after a new release of millions of documents exposed details of his closeness to Epstein, including suggestions of payments to Mandelson and his husband.
The scandal has sparked concerns about Starmer’s decision to appoint Mandelson as ambassador instead of a career diplomat, a decision advocated by his chief of staff, Morgan McSweeney.
Labour lawmaker Clive Efford, speaking in parliament on Monday, said the “key question here is who advised the prime minister?”
Mandelson has not responded to requests about the allegations. A spokesperson, however, has said Mandelson had no recollection of financial payments, totalling $75,000, from Epstein, as suggested by other emails and media reports.
In an interview with the Times conducted late last month and published on Tuesday, Mandelson said Epstein had been a “master manipulator.” He added: “I’ve had a lot of bad luck, no doubt some of it of my own making.”
Starmer, seeking to get on the front foot after some of his lawmakers said Downing Street’s initial response over the weekend was not strong enough, has ordered an investigation into Mandelson’s links with Epstein during Brown’s government.
Brown, however, pre-empted him, saying that he had asked officials to look into the matter back in September but that he had been told they had unearthed no departmental records.
The former prime minister said on Monday that after the “shocking new information” came to light in the latest tranche of Epstein papers, he had asked for “a wider and more intensive inquiry to take place.”
Starmer has also called for the former Prince Andrew to testify before a US congressional committee, following new revelations about his links to Epstein.
Asked about the situation at a meeting in Dubai on Tuesday, Prince Edward, Andrew Mountbatten-Windsor’s younger brother, said: “It’s really important always to remember the victims,” echoing previous statements from King Charles and Queen Camilla.
A Thames Valley Police spokesperson said the force was aware of allegations that a woman was taken to an address in Windsor, where the former prince resides, for sexual purposes in 2010.
The woman’s lawyer told the BBC over the weekend that the woman, who is not British, was in her 20s at the time and was allegedly sent to Britain by Epstein for a sexual encounter with Mountbatten-Windsor. He has always denied any wrongdoing.
“We are assessing the information in line with our established procedures,” the police spokesperson said, adding that the force takes any reports of sexual crimes extremely seriously.
A review does not necessarily lead to an investigation.
Tim Bontemps is a senior NBA writer for ESPN.com who covers the league and what’s impacting it on and off the court, including trade deadline intel, expansion and his MVP Straw Polls. You can find Tim alongside Brian Windhorst and Tim MacMahon on The Hoop Collective podcast.
Meanwhile, will the Milwaukee Bucks find the right trade partner for Giannis Antetokounmpo between now and the deadline? If so, it could create a chain reaction of movement from teams previously on the sidelines.
Here’s a look at what we’ve heard about what has happened so far, what could happen over the next few days, and what it will mean for the rest of this season and beyond.
Bontemps: Charania has reported that the Cavaliers are the team most interested in a Harden deal. For Cleveland to do that, as the NBA’s only team over the second apron, the one realistic construction of a deal involves the Cavs sending out their own All-Star point guard, Darius Garland. And while two All-Star point guards potentially being swapped for one another is big news on its face, this deal is about another All-Star: Donovan Mitchell.
The Cavaliers know they are facing a huge decision this summer, one year before Mitchell can become a free agent in the 2027 offseason. If the Cavaliers again exit in the first or second round — as Mitchell has in each of his first eight seasons — will he be willing to commit to another extension in Cleveland? That seems unlikely. No one is more aware of that than the Cavaliers, who have already made one deal and are clearly interested in making more between now and Thursday afternoon.
Windhorst: Harden was nowhere to be found at Intuit Dome on Monday night, missing his second consecutive game for what the team called personal reasons. That he had perhaps played his last game for the Clippers, though, was not a secret on the floor. Players from both teams, the Clippers and the Philadelphia 76ers, whispered about the situation before the game and even chatted before tip about the concept of him ending up in Cleveland. With a handful of Clippers players wearing Harden’s signature shoes (which is normal), LA fell down 16-2 out of the gate looking flat. It was the second night of a back-to-back and that happens, but Harden’s tenure in LA has been marked by him carrying the team through tough times and it felt as if the team was expressing itself knowing what was taking place.
As for the possible transaction itself, whether Harden goes to Cleveland or elsewhere, he has a unique contract that plays a factor. He has the ability to block any trade, so the Clippers must work with him. Next season is a player option at $42 million, but it functions like a mutual option because only $13 million of it is guaranteed. Harden has asked for a trade three times previously in his career and all three times — in Houston, in Brooklyn and in Philadelphia — he has gotten it. He knows how to work the system and either getting that option fully guaranteed or getting an understanding on a new contract could well be a part of the negotiation.
Bontemps: By the way, a big winner of this potential trade? The Oklahoma City Thunder. The Clippers have been one of the NBA’s hottest teams over the past few months, and are 17-5 in their past 22 games after Monday night’s loss to the 76ers. It’s hard to see LA keeping up that pace by swapping out Harden for Garland, who has missed most of the past year with various foot issues. Oklahoma City, of course, has the Clippers’ unprotected first-round pick — part of the Paul George trade that keeps on giving.
Windhorst: The idea of this deal struck league executives as potentially awkward for both teams. While Harden is having a strong season, his timeline does not match the rest of the Cavs’ roster. Garland is dealing with issues to both big toes and, while sources said he is making progress after missing the past two weeks with a right toe sprain and could return soon, there is some concern about whether the injuries could be a longer-term issue. The Clippers had won 17 of 21 games before Monday night, completely turning around their season. Harden potentially jumping ship now, and its potential effect on the Clippers’ trajectory, certainly won’t be burnishing his résumé.
What is the latest on Giannis?
Windhorst: Only the Bucks know the exact landscape. It is possible that general manager Jon Horst and Milwaukee’s front office have the basis of an offer they’d pursue and it could get serious. Rival teams, however, believe it makes a lot of sense to wait until summer. The possible big offer from Golden State, a deal that could net Milwaukee up to four first-round picks, will likely still be there in June.
Meanwhile, the Bucks can wait until they know exactly where their pick and every first-rounder will land. Plus numerous possible suitors, such as the Miami Heat, can offer a better package of picks once the league year flips.
Bontemps: One Western Conference executive told me that “Everyone is preparing for this to happen in the summer.”
Another factor that could inform offseason Giannis trade talks? The upcoming playoffs — which have a chance to be truly chaotic. Eliminated contenders who feel they are “one star away” could pick up the phone, and Milwaukee could be in a position to take full advantage. As another longtime executive is fond of saying, “Disappointment leads to action.”
By waiting until the summer, and waiting to see what happens, it increases the chances of the Bucks being able to leverage their position in the strongest way possible. While it’s hard to see it working out in exactly the same way it did for the Thunder, the Paul George trade back in 2019 — which Thunder general manager Sam Presti knew would lead to the Clippers landing Kawhi Leonard — turned into a treasure trove of assets that is still benefitting OKC.
Milwaukee is in a big hole from an asset standpoint right now, but an Antetokounmpo trade could quickly change that.
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1:36
How could a Giannis-to-Warriors trade work?
Bobby Marks uses the NBA Trade Machine to break down how the Warriors and Bucks could match up on a trade for Giannis Antetokounmpo.
Is AD now off the trade market?
Bontemps: With Davis sidelined because of a hand injury, the belief around the league for weeks has been that the trade deadline will pass without a move. Davis has also made it clear he wants to stay in Dallas. So why is this still coming up?
Windhorst: This will largely depend on what Dallas is willing to do with the expected return. In initial talks with teams, the Mavs were looking for a premium, including multiple first-round picks or a prime player, per sources — textbook stuff when making a star available. There is also the matter of Davis eyeing an extension this summer. There were no takers.
If Dallas reduces its demands by electing to take back expiring salaries and perhaps one good asset, the possibility of an AD deal increases. That’s probably a late Wednesday or early Thursday scenario. The Mavs could just as easily wait, as there is no longer any pressure on this season.
Bontemps: Rival teams expect the Mavericks to pursue other moves to trim money. Veterans such as Klay Thompson, Daniel Gafford and D’Angelo Russell all could find new homes this week, and any expiring money that comes back would allow the Mavericks to reset their books for next season, lessening the need to move Davis now to avoid a gigantic luxury tax bill next year. Owner Patrick Dumont can then decide how to build his front office — currently run by co-interim GMs Matt Riccardi and Michael Finley — and let them decide directions for Davis, Kyrie Irving and the rest of the roster around 19-year-old Cooper Flagg.
What will Giannis suitors do if he isn’t moved?
Windhorst: The Warriors have limited time left in the Stephen Curry experience and have more incentive to acquire Antetokounmpo now for a postseason run instead of during the summer. That’s why they are believed to be quite aggressive. Golden State does have the prickly matter of trying not to offend players who might be in the offer, and that already has been a talking point.
Bontemps: Miami has been preserving cap space for 2027, and I don’t see the Heat deviating from that plan. That is, unless they can get Antetokounmpo. The New York Knicks are so limited in draft assets that they don’t have much maneuverability. If they can’t get an Antetokounmpo deal done, it’s unlikely they’ll do anything beyond tinkering around the edges (such as moving on from Guerschon Yabusele, for example).
If Minnesota can’t land Antetokounmpo, could the Wolves find their point guard of the future? The franchise has been searching for Mike Conley‘s long-term successor for years to no avail, including drafting Rob Dillingham two years ago in a move that hasn’t panned out. Perhaps one finally will this week.
What else are you watching this week?
Windhorst: Based on my conversations around the league, the Timberwolves could be very active. Like the Cavs, the Wolves are invested in a mature team operating under heavy expectations. They’ve had their moments this season, including two wins over the Thunder, but the Wolves generally would prefer to be higher in the standings. As a relic of the trades used to build this roster, Minnesota has limited draft assets, which means trade discussions have been player-driven. The Wolves have been investigating backcourt options in addition to trying to pry themselves into Antetokounmpo talks.
Bontemps: In addition to the fascinating situation in Cleveland, other places I’m watching this week include Memphis, Boston, Toronto and Indiana.
The Grizzlies have made Morant available for weeks, but sources have been skeptical of general manager Zach Kleiman finding a deal. Heading into this week, those same sources were more interested in whether Jaren Jackson Jr. would be moved. Those questions were answered on Tuesday, when the Utah Jazz acquired the former Defensive Player of the Year in a deal that netted Memphis three future first-round picks.
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1:07
Charles Barkley rips the Cavs-Kings trade
Charles Barkley explains why the Cavaliers, Kings trade including DeAndre Hunter, Keon Ellis and Dennis Schroder makes no sense for either side.
The Celtics had been expected to pursue center help all season, especially if their new-look roster made its way into the playoff picture. Now that Boston is ahead of schedule, the front office had the chance pair a deadline move with the possible return of Jayson Tatum from a torn Achilles this season. Enter big man Nikola Vucevic, who sources told Charania on Tuesday is headed to Boston in a deal that sends guard Anfernee Simons to the Chicago Bulls. Depending on this trade’s construction, Boston could get out of the luxury tax.
The Raptors have been linked to big names throughout this cycle and continue to impress this season. One name several sources have connected to the Raptors is Kings big man Domantas Sabonis. The Kings, bumping up against the luxury tax for next season after Saturday’s Hunter trade, will need to shed some salary. Toronto, meanwhile, would also be hoping to duck the tax in such a move.
The Pacers, without the injured Tyrese Haliburton, sit near the bottom of the standings and will likely net a high lottery pick in the loaded 2026 draft this year as a result. But for weeks, rival teams have spotlighted Indiana as a contender for “pre-agency,” adding talent now to help regain its elite status when Haliburton returns in 2026-27. The Pacers continue to seek a long-term answer at center after free agent Myles Turner left for Milwaukee last summer. And with Bennedict Mathurin headed for restricted free agency this offseason, the expectation among sources is he could be moved either to acquire center help or to find a cheaper long-term wing option.
The unnamed LSU student-athlete investigated by the College Sports Commission for non-reporting of third-party NIL deals will not face disciplinary action, the school confirmed Monday.
“The CSC inquiry into non-reporting has been resolved with no disciplinary action, and any deals that require submission to NIL Go have been submitted. We appreciate the CSC’s prompt review and resolution,” LSU deputy AD for external affairs Zach Greenwell said in a statement.
The CSC, an NIL enforcement entity that oversees revenue sharing in college sports, said Monday it had informed several schools of investigations regarding unreported NIL deals.
Student-athletes must report third-party NIL deals exceeding $600 through NIL Go, the clearinghouse introduced alongside the landmark $2.8 billion settlement approved in early June.
LSU confirmed at least one of its athletes was being investigated at the time. According to multiple reports, it was not a football player and not a department-wide investigation.
Information from The Associated Press was used in this report.
PepsiCo on Tuesday reported quarterly earnings and revenue that topped analysts’ expectations, fueled by improving organic sales across its business.
Demand for the company’s snacks has been sluggish as consumers balk at higher prices. This year, Pepsi plans to lower prices on products like chips from its North American food division to “improve competitiveness and the purchase frequency of our brands,” executives said in prepared remarks. Productivity savings will offset the lower prices, they said.
Shares of the food and beverage giant closed nearly 5% higher on Tuesday.
Here’s what the company reported compared with what Wall Street was expecting, based on a survey of analysts by LSEG:
Earnings per share: $2.26 adjusted vs. $2.24 expected
Revenue: $29.34 billion vs. $28.97 billion expected
Pepsi reported fourth-quarter net income attributable to the company of $2.54 billion, or $1.85 per share, up from $1.52 billion, or $1.11 per share, a year earlier.
Excluding restructuring and impairment charges and other items, the company earned $2.26 per share.
Net salesrose 5.6% to $29.34 billion. Organic revenue, which strips out foreign currency, acquisitions and divestitures, increased 2.1% in the quarter.
“PepsiCo’s fourth quarter results reflected a sequential acceleration in reported and organic revenue growth, with improvements in both the North America and International businesses,” CEO Ramon Laguarta said in a statement.
However, the company is seeing volume declines, particularly for its North American businesses. The metric excludes pricing and foreign exchange fluctuations to reflect demand more accurately.
Global volume for its food fell 2% in the quarter, although global volume for its drinks ticked up 1%.
Pepsi’s home market was once again the weak point of the quarter, although it is showing signs of improvement. Inflation-weary shoppers have been buying less of Pepsi’s snacks and drinks in a sign of consumer backlash against higher prices. “Affordability” is the biggest obstacle to attracting low- and middle-income consumers, Laguarta said on the company’s conference call.
PepsiCo Beverages North America, which includes Gatorade, Starry and Poppi, saw volume shrink 4%, though its organic sales rose 2%.
PepsiCo’s North American food division, which spans brands from Quaker Oats to Cheetos, reported that volume fell 1%. Although it reported higher volume growth than the North American beverage unit this quarter, Pepsi’s domestic food business has been the laggard of the portfolio for more than a year.
Retailers that sell Pepsi products have responded to the price cuts with enthusiasm, according to executives. As a result, its products will become even more ubiquitous, starting this spring; the company expects a double-digit increase in shelf space with its top retail customers, on average.
To further improve demand for its snacks, Pepsi is planning to cut prices on some packages of select brands, including Lay’s, Tostito’s, Doritos and Cheetos, executives said in prepared remarks. In addition to price cuts, key brands, like Lay’s, Tostitos, Gatorade and Quaker have been undergoing makeovers that include simpler ingredients and new packaging to help bring back customers. Pepsi is also working on expanding its portfolio to include more functional drinks, whole grains, protein and fiber.
Pepsi also reiterated the outlook for 2026 that the company provided in December. The company is projecting that organic revenue will rise between 2% and 4% and core constant currency earnings per share will increase in a range of 4% to 6%.
In December, Pepsi struck a deal with activist investor Elliott Investment Management, which had revealed a roughly $4 billion stake in the company two months earlier. As part of the agreement, Pepsi said it would slash its U.S. product lineup by 20%, cut costs across its food and beverage operations, and lower snack prices. Elliott did not receive any seats on Pepsi’s board.
As Pepsi implements that plan this year, the company is projecting that its North American business will improve, while its international divisions remain “resilient,” according to Laguarta.
Stefon Diggs has hinted that a wedding proposal to Cardi B could be in the works, though he is focused on securing his own championship ring first.
Speaking at a media presser on Monday ahead of Super Bowl LX, the New England Patriots wide receiver was asked if his partner would be receiving a ring of her own if he wins the big game this Sunday.
Diggs laughed at the suggestion, responding, “It’s on the agenda, maybe, right? Right?”
However, he made it clear that the upcoming match against the Seattle Seahawks is his immediate priority, adding, “I gotta get mine first, though.”
The couple, who first sparked dating rumours in February 2025 before making their relationship Instagram-official last June, have had a whirlwind year.
They welcomed a son together in November 2025, adding to their busy family lives.
Cardi, 33, is currently a mother of four, sharing three children, Kulture, 7, Wave, 4, and one-year-old Blossom, with her former partner Offset, from whom she is currently divorcing.
Cardi B goes wild as Stefon Diggs heads to Super Bowl: ‘That’s my baby!’
Meanwhile, 32-year-old Diggs is a father to five other children, four of whom were born just last year.
Despite his focus on the pitch, Diggs remains a huge supporter of Cardi’s career and recently praised her performance on Saturday Night Live.
While he admitted he isn’t an expert on the music industry, he told PEOPLE, “I don’t know too much about music but I know she’s one of the best to ever do it and one of the best out right now.”
He expressed his excitement for her upcoming tour, noting that it falls during his football off-season, which should allow him to travel and support her in person.
He even joked about being a dedicated fan in the crowd, saying, “I’ma get me a big a** sign that says, ‘Go, go go go.’”
Cardi has fully embraced her role as a supportive partner, appearing at several of Diggs’ games, including the recent AFC Championship victory over the Denver Broncos.
She is also set for a busy Super Bowl weekend herself, with a scheduled performance at the Fanatics Super Bowl party on Saturday.
Diggs emphasised that he wants to see her continue to flourish and reach her potential as she balances her role as a mother with her global music career.
Puzzling cancer and Alzheimer’s link explored in new study: ‘SHORT QUOTE’
A new study may help clarify a long-observed link between cancer history and reduced Alzheimer’s risk.
The research, published in the journal Cell, used mouse models to explore how the biological changes associated with cancer may affect the progression of the most common dementia type.
The findings suggest that certain cancers release a protein called cystatin-C that can travel through the bloodstream and enter the brain, an area that many Alzheimer’s treatments have difficulty reaching.
Cystatin-C binds to harmful amyloid protein clumps linked to Alzheimer’s and activates a protein called TREM2, which acts like an on-switch for the brain’s immune cells.
When activated, those cells begin clearing away existing amyloid plaques, a process that was associated with reduced plaque buildup and improved cognitive function, the study found.
New research suggests that cancer-related biological changes may help explain why a history of cancer is linked to lower Alzheimer’s risk.(iStock)
Dr. Bob Arnot, a Vermont-based internal medicine physician, told Fox News Digital that the findings help clarify a pattern doctors have observed for years.
“Scientists have long observed a puzzling statistical pattern known as ‘inverse comorbidity’ — people with a history of cancer are less likely to develop Alzheimer’s disease, and people with Alzheimer’s are less likely to develop cancer,” said Arnot, who was not involved in the study.
Cystatin-C sticks to harmful amyloid clumps and turns on brain immune cells, helping them clear plaques and improve brain function.(iStock)
The findings suggest that biological signals tied to certain cancers may slow or reverse key features of Alzheimer’s disease.
Arnot said the research is notable because it identifies a specific biological pathway that could be targeted for future Alzheimer’s treatments.
“This approach targetsexisting amyloid plaques, not just early prevention. That distinction could be critical for patients who already have established disease,” he said.
The results suggest that cancer-related biological signals may help slow or even reverse some core aspects of Alzheimer’s disease.(iStock)
Arnot cautioned that the findings do not mean cancer itself is protective.
“This study does not suggest that cancer is protective, desirable or a viable therapy,” he said. “Instead, it reveals that biological programs activated during cancer can inadvertently engage protective immune mechanisms in the brain.”
The research suggests that future treatments could focus not just on slowing Alzheimer’s, but also on clearing harmful buildup in the brain, Arnot added.
The results were based on experiments in animal models, and further research is needed to determine whether the same effects occur in humans, the researchers noted.
Kelly McGreal is a production assistant with the lifestyle team at Fox News Digital.
Puzzling cancer and Alzheimer’s link explored in new study: ‘SHORT QUOTE’
A new study may help clarify a long-observed link between cancer history and reduced Alzheimer’s risk.
The research, published in the journal Cell, used mouse models to explore how the biological changes associated with cancer may affect the progression of the most common dementia type.
The findings suggest that certain cancers release a protein called cystatin-C that can travel through the bloodstream and enter the brain, an area that many Alzheimer’s treatments have difficulty reaching.
Cystatin-C binds to harmful amyloid protein clumps linked to Alzheimer’s and activates a protein called TREM2, which acts like an on-switch for the brain’s immune cells.
When activated, those cells begin clearing away existing amyloid plaques, a process that was associated with reduced plaque buildup and improved cognitive function, the study found.
New research suggests that cancer-related biological changes may help explain why a history of cancer is linked to lower Alzheimer’s risk.(iStock)
Dr. Bob Arnot, a Vermont-based internal medicine physician, told Fox News Digital that the findings help clarify a pattern doctors have observed for years.
“Scientists have long observed a puzzling statistical pattern known as ‘inverse comorbidity’ — people with a history of cancer are less likely to develop Alzheimer’s disease, and people with Alzheimer’s are less likely to develop cancer,” said Arnot, who was not involved in the study.
Cystatin-C sticks to harmful amyloid clumps and turns on brain immune cells, helping them clear plaques and improve brain function.(iStock)
The findings suggest that biological signals tied to certain cancers may slow or reverse key features of Alzheimer’s disease.
Arnot said the research is notable because it identifies a specific biological pathway that could be targeted for future Alzheimer’s treatments.
“This approach targetsexisting amyloid plaques, not just early prevention. That distinction could be critical for patients who already have established disease,” he said.
The results suggest that cancer-related biological signals may help slow or even reverse some core aspects of Alzheimer’s disease.(iStock)
Arnot cautioned that the findings do not mean cancer itself is protective.
“This study does not suggest that cancer is protective, desirable or a viable therapy,” he said. “Instead, it reveals that biological programs activated during cancer can inadvertently engage protective immune mechanisms in the brain.”
The research suggests that future treatments could focus not just on slowing Alzheimer’s, but also on clearing harmful buildup in the brain, Arnot added.
The results were based on experiments in animal models, and further research is needed to determine whether the same effects occur in humans, the researchers noted.
Kelly McGreal is a production assistant with the lifestyle team at Fox News Digital.
