How Safe Are Glutathione Injections? Doctors Reveal Risks Of Anti-Ageing Treatments

Last Updated:July 01, 2025, 17:31 IST

Health experts warn that while glutathione and NAD therapy are popular for cosmetic use, they aren’t risk-free and must be taken only under strict medical supervision

The sudden death of model and actress Shefali Jariwala at the age of 42 due to cardiac arrest has raised serious concerns about the safety of anti-ageing treatments. Known for maintaining a youthful appearance, Jariwala had reportedly been undergoing such therapies for years. Her death has sparked renewed scrutiny of intravenous (IV) treatments like glutathione and NAD therapy, which are gaining popularity as non-invasive alternatives to Botox.

What Is Glutathione And Why Is It Creating So Much Buzz

Glutathione, a powerful antioxidant produced naturally in the body, is now being used for skin lightening and anti-ageing therapy. Speaking to News18, Dr. Shankar Sawant, a Consultant Dermatologist at SL Raheja Hospital in Mumbai, explained that glutathione neutralises free radicals, detoxifies the liver, and supports the immune system.

Despite its benefits, the substance is being administered in doses much higher than recommended to achieve an instant glow and fair skin, leading to potential risks. High doses of glutathione—exceeding the safe limit of 20-40 mg per kg body weight per day—can cause arrhythmia, a drop in blood pressure, and other heart-related problems. It may also trigger allergic reactions. Notably, glutathione has not been medically approved for skin whitening; its approval is solely as an antioxidant.

Dr. Vichitra Sharma, Senior Consultant at Amrita Hospital’s Dermatology Department in Faridabad, highlights other popular anti-ageing treatments such as retinoids, chemical peels, botox, dermal fillers, platelet-rich plasma (PRP), and glutathione. Each treatment targets different layers of the skin and should be tailored to individual needs by a doctor.

How Safe Is Glutathione Therapy For The Heart?

Concerns about the safety of these treatments extend to heart health. Dr. Ashish Kumar, Senior Consultant in the Cardiology Department at Amrita Hospital, warns that anti-ageing treatments without medical supervision can lead to conditions like electrolyte imbalance, low blood pressure, and heart attacks. The danger lies not in the medicines themselves but in their misuse—taking high doses, combining them with other medications, or undergoing treatment without proper cardiac screening.

What Is NAD Therapy And Why Is It Gaining Popularity?

South Delhi’s renowned celebrity dermatologist Dr. Deepali Bhardwaj explained that while glutathione has been popular for several years, a new trend is now rapidly gaining traction: Nicotinamide Adenine Dinucleotide (NAD) therapy. Although NAD drips have been available for over 35 years, they have recently become one of the most sought-after anti-ageing treatments. Known for boosting energy, improving metabolism, and aiding in cell repair, NAD therapy is now regularly used by many celebrities.

Glutathione dominated the anti-ageing space for the past decade, but demand for NAD and similar treatments has surged in the last 3–4 years. Dr. Bhardwaj clarified that when administered properly under professional supervision, these treatments are generally safe. The real risk lies in counterfeit products, unqualified practitioners, or inappropriate clinical settings. For instance, taking a glutathione or NAD drip on an empty stomach and then exercising without eating can lead to a sudden drop in blood pressure, potentially triggering cardiac arrest.

Are All Anti-Ageing Treatments Risky?

According to health experts, while glutathione and NAD therapy are gaining popularity for cosmetic enhancement, they are not risk-free shortcuts to youthful skin. These treatments must be administered strictly under medical supervision. A thorough evaluation of the patient’s medical history and current health status is essential before starting any such therapy.

Experts warn that due to a lack of strict regulation, the market is flooded with counterfeit products and untrained practitioners. Incorrect dosages or poorly timed administration can turn these so-called “glow” treatments into life-threatening risks. Hence, extreme caution and professional oversight are critical.

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